Review





Similar Products

aav ctr  (Bioprofile Testing)
86
Bioprofile Testing aav ctr
a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice <t>(AAV-CTR</t> n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.
Aav Ctr, supplied by Bioprofile Testing, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aav+ctr/aav+ctr/pmc13035944-366-6-33
Average 86 stars, based on 1 article reviews
aav ctr - by Bioz Stars, 2026-11
86/100 stars
  Buy from Supplier
adeno-associated virus (aav)-sh-ctr  (Shanghai GenePharma)
90
Shanghai GenePharma adeno-associated virus (aav)-sh-ctr
a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice <t>(AAV-CTR</t> n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.
Adeno Associated Virus (Aav) Sh Ctr, supplied by Shanghai GenePharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aav+ctr/adeno+associated+virus++aav++vectors/pm39777430-44-0-5
Average 90 stars, based on 1 article reviews
adeno-associated virus (aav)-sh-ctr - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier
aavs encoding the noplight-ctr sensor  (Vigene Biosciences)
90
Vigene Biosciences aavs encoding the noplight-ctr sensor
a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice <t>(AAV-CTR</t> n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.
Aavs Encoding The Noplight Ctr Sensor, supplied by Vigene Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aav+ctr/aavs+encoding+the+noplight+ctr+sensor/pmc11199706-348-1-13
Average 90 stars, based on 1 article reviews
aavs encoding the noplight-ctr sensor - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier
aav-ctr  (Genechem)
90
Genechem aav-ctr
a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice <t>(AAV-CTR</t> n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.
Aav Ctr, supplied by Genechem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aav+ctr/aav+ctr/pm37635201-311-9-12
Average 90 stars, based on 1 article reviews
aav-ctr - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier
shrna-aav targeting ctr-a/b  (OriGene)
90
OriGene shrna-aav targeting ctr-a/b
a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice <t>(AAV-CTR</t> n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.
Shrna Aav Targeting Ctr A/B, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aav+ctr/shrna+aav+targeting+ctr+a+b/pmc04443949-247-3-16
Average 90 stars, based on 1 article reviews
shrna-aav targeting ctr-a/b - by Bioz Stars, 2026-11
90/100 stars
  Buy from Supplier

Image Search Results


a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice (AAV-CTR n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: A neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of PKN1

doi: 10.1038/s41467-026-68916-0

Figure Lengend Snippet: a Boxplot of human parahippocampal transcriptome data from MSBB showing activated PKN1-5a1 cryptic splicing in AD samples across Braak stages. Box plots show median (center line), the upper and lower quantiles (box), and the range of the data (whiskers). b Schematic of bilateral hippocampal AAV injection in C57BL/6J mice and subsequent behavioral testing. c Morris water maze showing prolonged escape latency in AAV-PKFL and AAV-PKN207 mice (AAV-CTR n = 9, AAV-PKFL n = 10, AAV-PKN207 n = 10, repeated-measures two-way ANOVA). d CSF NEFL levels are elevated in AAV-PKN207 mice (AAV-CTR n = 10, AAV-PKFL n = 20, AAV-PKN207 n = 20; one-way ANOVA). e Primary hippocampal neurons expressing PKFL or PKN207 showing increased LDH release ( n = 4, one-way ANOVA). f KEGG enrichment of DEPs highlights pathways linked to synaptic function and neurodegeneration. g Heatmap showing downregulation of LTP-related genes in PKN207-expressing mice. h STRING network of NEFL-interacting proteins (red: upregulated; blue: downregulated). i Western blots of neurofilament proteins in N2a cells overexpressing PKFL or PKN207. j Hippocampal LTP is impaired in AAV-PKN207 mice; fEPSP slopes are shown (5 mice, 10 slices; one-way ANOVA). Source data are provided as a Source Data file.

Article Snippet: Hippocampus stored at −80 °C from AAV-CTR, AAV-PKN207, and AAV-PKFL mice, with three biological replicates per group, following protein extraction and trypsin digestion, peptides were combined in equal amounts and submitted to Shanghai Bioprofile Biotechnology Co., Ltd. for data-independent acquisition (DIA) using the Orbitrap Astral platform.

Techniques: Injection, Expressing, Western Blot